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mitotane will lower the extent or influence of abemaciclib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Coadministration of abemaciclib with potent CYP3A4 inducers cuts down plasma focus of abemaciclib and its metabolites.Ideal reports haven't been done on the relationship of age to the results of abemacicl